Lesson 2: How Medical Cannabis Works in the Body

Medical cannabis works through the body’s endocannabinoid system,

a network involved in regulating functions such as pain signaling, mood, sleep, appetite, and stress response. Cannabinoids—such as THC and CBD—can interact with this system in different ways, which helps explain why effects may vary from person to person.

THC is the primary cannabinoid associated with intoxication or impairment, while CBD is typically non-intoxicating. Products may contain different ratios of these compounds, and the same product can feel different depending on dose, timing, and individual sensitivity.

Effects also depend on the form used. Inhaled products tend to take effect more quickly and wear off sooner, while oral forms often take longer to start and may last longer. For safety, many patients are advised to begin with a low dose and adjust gradually over time based on response and tolerability.

This lesson is educational and meant to support informed conversations during clinical care. If you have questions about how medical cannabis may affect you specifically—including interactions with medications—discuss them during your evaluation or follow-up.